Glendenning is located 44 kilometres west of the Sydney central business district, in the local government area of the City of Blacktown and is part of the Greater Western Sydney region. It is quite close to the suburbs of Plumpton, Dean Park and Rooty Hill. By road Glendenning is adjacent to the Westlink M7 motorway which can provide very easy access to the Great Western Highway and the M4 Motorway, providing road access to the western sections of the city and eastward to the Sydney CBD. While there are limited commercial and retail outlets within Glendenning, Emerton, Plumpton, and Mount Druitt are all in very close proximity and offer access to a wide range of supermarkets, banks, and discount department stores.